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Gerald Litwack

Gerald Litwack, American biochemistry researcher, educator, administrator. Achievements include discovery and identification of the glucocorticoid receptor; co-discovery of ligandin (glutathione S-Transferase family) mechanism of glucocorticoid receptor activation, studies in apoptosis, immunophilin signal transduction, basic studies in asthma, glucocorticoid induced gene expression.

Background

  • Litwack, Gerald was born on January 11, 1929 in Boston, Massachusetts, United States. Son of David and Edith Jean (Berkman) Lytell.

  • Education

    • Bachelor, Hobart College, 1949. Master of Science, University Wisconsin, 1950. Doctor of Philosophy, University Wisconsin, 1953.

    Career

    • Postdoctoral fellow Bio-chemical Laboratories University Paris, 1953-1954. Assistant professor Rutgers University, New Brunswick, New Jersey, 1954-1960. Trainee Oak Ridge Institute Nuclear Studies, 1955.

      Associate professor University Pennsylvania, Philadelphia, 1960-1964. Carnell professor, deputy director Fels Institute, School of Medicine Temple University, 1964-1991. Professor, chair department pharmacology Thomas Jefferson University, 1991-1996, also deputy director Kimmel Cancer Institute, 1991-1997.

      Associate director for basic science Kimmel Cancer Center, 1992-1997, professor, chairman department biochemistry and molecular pharmacology, 1996—2003, emeritus, 2003, director Center Apoptosis Research, associate dean science affairs, 1996-2001, vice dean for research, 2001—2003. Visiting scholar Department Biological Chemistry David Geffen School Medicine University of California at Los Angeles, since 2004. Chairman advisory committee american Cancer Society, New York City, 1977-1980.

      Member advisory panel National Science Foundation, Washington, 1980-1984. Member ad hoc panels National Institutes of Health, Bethesda, 1985, 89, reviewer, 1977, 84, 91, consultant National Institute Environmental Health Science, 1982. Member ad hoc panels Israel Cancer Research fund Science Review Panel, 1992-1993, United States Army Breast Cancer Study Section, 1994.

      Member United States Army Neurotoxicology and Neurodegeneration Study Section, 1997, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, subcommittee B Study Section,1998, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, Primary Reviewer Molecular Endocrinology,2003, others. Councilor Society for Experimental Biology and Medicine, New York City, 1984-1988. Consultant Franklin Institute, 1976, Georgetown University, 1980.

      Reviewer Haverford College, 1976, National Institutes of Health programs, 1984, 91. Member advisory board Diabetes Research Center University Pennsylvania, since 1996. Member joint steering committee for public policy Rockville, Maryland, since 1997.

      Evaluator Roswell Park Memorial Institute, 1978. Member science advisory board Norris Cotton Cancer Center Dartmouth Medical School, since 1984. Jefferson representative University Catania, Sicily, 1994— 2001, U Naples, Italy, since 2001.

      Member subcommittee B study section National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 1998. Member subcommittee on research Sharpe-Strumia Foundation, since 1998. External reviewer National Institute of Child Health and Human Development, National Institutes of Health, 1999.

      Visiting professor University California, Berkeley, 1956, University California, San Francisco, 1972. Honorary professor biochemistry Rutgers University, 1957-1960. Visiting scientist Courthauld Institute Biochemistry, University London, 1971.

      Member study section SPORE breast and prostate cancer research, National Institutes of Health and National Cancer Institute, 2000-2001. Visiting scholar department biological chemistry David A. Geffen School Medicine at University of California at Los Angeles, 2004^.

    Major achievements

    • Achievements include discovery and identification of the glucocorticoid receptor. Co-discovery of ligandin (glutathione S-Transferase family) mechanism of glucocorticoid receptor activation, studies in apoptosis, immunophilin signal transduction, basic studies in asthma, glucocorticoid induced gene expression.

    Membership

    Board directors Sharpe-Strumia Foundation Bryn Mawr Hospital, 1997—2003. Member Endocrine Society (program committee 1991-1993, science and education committee 1992-1993, annual meeting steering committee 1990-1993, committee on science and educational programs 1992-1993), American Society Biochemistry and Molecular Biology, American Society Pharmacology and Experimental Therapeutics, American Association Cancer Research (chair task force on endocrinology 1995, endocrinology and signal transduction subcommittee, program committee, 1995-1996, Tellers Committee, 2002), American Chemical Society, Association of America Medical College (GREAT group 1997—2003, congressional liaison 1998-2003), Association for Medical School Pharmacology, Association of Medical and Graduate Department of Biochemistry.

    Connections

    • Married Patricia Lynn Gorog, February, 1956 (div. 1973); 1 child, Claudia. Married Ellen Judith Schatz, August 31, 1973.

      Children: Geoffrey Sandor, Katherine Victoria.
    • father: David Lytell
    • mother: Edith Jean (Berkman) Lytell
    • spouses: Patricia Lynn Gorog
    • Ellen Judith Schatz
    • children: Claudia Litwack
    • Geoffrey Sandor Litwack
    • Katherine Victoria Litwack
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    Born January 11, 1929
    Nationality
    • 1949
      Hobart College
    • 1950
      University Wisconsin
    • 1953
      University Wisconsin
    • 1953 - 1954
      Postdoctoral fellow, Bio-chemical Laboratories University Paris
    • 1954 - 1960
      assistant, professor Rutgers University
      New Brunswick, Canada
    • 1955
      trainee, Oak Ridge Institute Nuclear Studies
    • 1960 - 1964
      associate, professor University Pennsylvania
      Philadelphia, Pennsylvania, United States
    • 1964 - 1991
      Carnell professor, Fels Institute
    • 1964 - 1991
      deputy director, Fels Institute
    • 1991 - 1996
      professor
    • 2001 - 2003
      associate, director for basic science Kimmel Cancer Center
    • 2003
      associate, director for basic science Kimmel Cancer Center
    • 2004
      visiting scholar, Department Biological Chemistry David Geffen School Medicine University of California at Los Angeles
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