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Hari Shanker Sharma

  • Background

    Hari Shanker Sharma was born on Jan 15, 1955 in an Industrialist town Dalmianagar (Bihar), India in a well-reputed family: Father Shri Ram Rup Sharma, M.Eng. (Cal), and one of the founders of Paper Factory under Rohtas Industries Ltd.
  • Education

    • Hari Sharma did his Higher Secondary Schooling in 1969 from Dalmianagar and enrolled in Bihar University, Muzaffarpur for higher studies. He did his Bachelor of Science with Honors from the prestigious L S College Muzaffarpur in 1973 and secured 1st position in his batch. He obtained his Master Degree from Bihar University with

      special expertise in Cell Biology in 1976 and awarded Gold Medal of Bihar University for securing 1st potion in the 1st Class. Having a knowledge in cell biology with special interest in the central nervous system, Hari Sharma joined the group of Professor Prasanta Kumar Dey, a neurophysiologist by training in the Department of Physiology, Institute

      of Medical; Sciences, Banaras Hindu University, Varanasi in 1977 to obtain Doctor of Philosophy Degree (D. Phil) in Neurosciences. In the lab he conducted experiments on morphine dependence and withdrawal in relation to body temperature regulation, behavioral changes and neurochemistry in rat and mice models. In addition he was trained as

      neurophysiologist to record electrophysiological activity in relation to stress, hypertehrmia and drugs of abuse.


    • Hari Sharma was always fascinated by the role of blood-brain barrier (BBB) in various experimental conditions and wanted to know whether brain disease has any relation with the spontaneous disruption of the BBB. His curiosity about the role of the BBB breakdown in stress condition leading to mental diseases was the basis of his Doctoral studies on “Blood-Brain Barrier in Stress” in which he for the first time showed that long or short term stress can disrupt the BBB and disrupts the EEG activity. These changes can be altered by drugs capable to modulate neurochemical metabolism of serotonin, prostaglandins and opioids in the CNS. On this work, he was awarded Ph D in 1982, that was examined and approved by the renowned team of experts on the BBB, namely: the father of Blood-Brain Barrier Research, Stanley I Rapoport of NIH, Bethesda, Maryland, USA; a pioneer on BBB in hypertension Professor Barbro Johansson, Department of Neurology of Lund University, Lund, Sweden; and noted Neuroanatomist with special regard to BBB Erik Westergaard, University of Copenhagen, Copenhagen, Denmark.

      Hari Sharma after carrying out a series of Govt. of India funded Research Projects on the BBB and brain dysfunction (1982-1987), joined the lab of Neuropathology at Uppsala University with Professor Yngve Olsson in 1988 to expand his knowledge on the passage of tracer transport across the BBB in stress caused by traumatic insults to the Brain and Spinal cord at light and electron microscopy. Dr Sharma awarded the prestigious Alexander von Humboldt Foundation Fellowship of German Govt. (1989-1991) to work on hypertehrmia induced BBB dysfunction at the ultrastructural level in the laboratory of Professor Jorge Cervós-Navarro (recognized as living “Legends in Neuropathology in Europe”, World Federation of Neuropathology in 1990, Kyoto, Japan, and later awarded with the German Govt. highest Civil Award, Bundestag by German Chancellor in1996). After that Dr Sharma came back to Uppsala to continue his research on Neurotrauma and established a network of collaboration on “Experimental CNS Injury Research Group” with key collaborators in various parts of Europe, USA, and Australia including his parent Institutions in India that is still continuing. The works carried out by Dr Sharma on the pathophysiology of blood-brain barrier in hypertehrmia using immunohistochemistry and electronmicroscopy in the Neuroanatomy Department of Uppsala University (1995-1999). On his work on hyperthermia Dr Sharma was decorated with prestigious Neuroanatomy award “Rönnows Research prize” of Uppsala University for “best neuroanatomical research of the year 1996” followed by the Award of the Degree of Doctor of Medical Sciences of Uppsala University in Neuroanatomy in 1999 (examined and approved by another legend of Blood-brain barrier Research, Professor David Begley, Kings College London, UK). The Uppsala University Thesis of Dr Sharma was also selected for the Best Thesis Award of the Medical faculty, “The Hwassers Prize” of 1999. Subsequent research of Dr Sharma in Uppsala University on the neurobiology of hypertehrmia in relation to the Blood Brain barrier and Brain edema (2000-2003) has earned the prestigious title of Docent in Neuroanatomy of Medical Faculty, Uppsala University (approved and recommended by eminent neuroanatomist, Professor Ole Petter Ottersen, University of Oslo, Norway) in April 2004.


    • Fellow: American Institute Stress; American Association for the Advancement of Science,

    • Serotonin Club,

    • European Neuropeptide Club,

    • International Society Neuropathology,

    • New York Academy Scis.,

    • International Brain Edema Research Society,

    • International Brain Research Organization,


    • Mother: Doeraj
    • Father: Ram
    Born January 15, 1955
    (age 60)
    • 1973 - 2000
      studied at Bihar University, honors, Bachelor of Science
    • 1976 - 2000
      studied at Bihar University, Master of Science
    • 1982 - 2000
      studied at Banaras Hindu University, Doctor of Philosophy
    • 1983 - 1986
      Research scientist, A Banaras Hindu University
    • 1999 - 2000
      studied at Uppsala University, DMSC
    • 2000
      research scientist, A Banaras Hindu University
    • 2000
      research scientist, Uppsala University
    • 2000
      professor, neurobiology
    • 2000
      docent, in neuroanatomy
    • show more ...


    Diana Sarkar last changed 28/06/2012 view changes
    • Career
      • A Banaras Hindu University
        • Location
        • Position
        • Start date
        • Finish date
      • Uppsala University
      • neurobiology
      • in neuroanatomy
      • A Banaras Hindu University
      • in neuroanatomy, 2000
      • neurobiology, 2000
      • Uppsala University, 2000
      • A Banaras Hindu University, 2000
    • Awards
      • Humboldt fellow
        • Awards description
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